follicular carcinoma with clinical phenotype of "hot nodule"
*based on 15 hot nodules investigated by Porcellini et al. 1994, Parma et al. 1997, Russo et al. 1996, Nogueira et al. 1999, Gozu et al. 2005 and 2006, Trulzsch et al. 2001 and Palos-Paz et al. 2008
and on 1 activating sporadic germline mutation investigated by Bircan et al. 2008
and on 1 hot thyroid carcinoma investigated by Führer et al. 2003
cAMP (basal): basal in vitro cAMP production of mutant over wild-type TSHR
cAMP (TSH): maximal in vitro cAMP production of mutant over wild-type TSHR
IP (basal): basal in vitro IP production of mutant over wild-type TSHR
IP (TSH): maximal in vitro IP production of mutant over wild-type TSHR
TSH-binding: maximal TSH-binding compared to the wild-type TSHR
Cell surface expression: cell surface expression of mutant compared to WT-TSHR
LRA: linear regression analysis (LRA) of constitutive activity as a function of TSHR expression determined by 125I-bTSH binding or FACS analysis compared to the wild-type TSHR
Prevalence: Prevalence of (somatic and germline) activating mutations*
Ref: Reference for functional characterization
Child: Found in children.