follicular carcinoma with clinical phenotype of "hot nodule"
* based on 13 hot nodules investigated by Parma et al. 1995 and 1997, Trülzsch et al. 2001, Van Sande et al. 1995, Tonacchera et al. 2000, Gozu et al. 2006, Paloz-Paz et al. 2008 and Georgopulos et al. 2003
and 2 hot thyroid carcinomas investigated by Camacho et al. 2000 and Bircan et al. 2005
cAMP (basal): basal in vitro cAMP production of mutant over wild-type TSHR
cAMP (TSH): maximal in vitro cAMP production of mutant over wild-type TSHR
IP (basal): basal in vitro IP production of mutant over wild-type TSHR
IP (TSH): maximal in vitro IP production of mutant over wild-type TSHR
TSH-binding: maximal TSH-binding compared to the wild-type TSHR
Cell surface expression: cell surface expression of mutant compared to WT-TSHR
LRA: linear regression analysis (LRA) of constitutive activity as a function of TSHR expression determined by 125I-bTSH binding or FACS analysis compared to the wild-type TSHR
Prevalence: Prevalence of (somatic and germline) activating mutations*
Ref: Reference for functional characterization
Child: Found in children.